His current research interests are in health information systems, patient safety, biomedical informatics education, and management of healthcare. He is the organiser for more than ten years of the International Conference on Informatics, Management, and Technology in Healthcare.
Professor Mantas is author of more than 250 publications. He is the author and the main editor of seven books published by international publishers in English. He is serving in many international scientific publications as associate editor and reviewer.
He led many European projects and initiatives in the field of Health Informatics. He was the President of the European Federation for Medical Informatics from 2010 to 2012. He is currently Vice-President of IMIA representing EFMI.